Maze to metastasis

Excited to see that our Perspective article has inspired the cover of the latest issue of Nature Reviews Immunology: a maze to metastasis designed by Simon Bradbrook.

Our article discusses what it takes for a disseminated tumor cell to grow at distance, putting forward the hypothesis that this is largely determined by the immune context at the site. We discuss how site-specific differences in local immune cell types, ratios and spatial locations might be a major selective growth restraint on disseminated tumor cells, and argue that harnessing tissue immunity will be essential for the next stage in immunotherapy development that reliably prevents the establishment of metastases.